Cultivated plants rarely produce fruits. The FDA said Phoenix Biotechnology provided evidence of a history of medicinal use of Nerium oleander extracts and some evidence of preclinical and … There was also an increase in HDL levels at doses of 10, 30, and 100 mg/kg.Gayathri 2013, In a study in rats, N. oleander distillate supplementation (375 mcg per 0.5 mL of distilled water by gavage daily for 90 days) decreased the high blood cholesterol levels in the group that consumed a high-fat diet. Extensive iron accumulation was found in the liver. Topical treatment with NAE-8 twice daily (2 mL/kg/day) for 14 days showed promising results in wound treatment. Up-regulation of the BAAT gene with N. oleander supplementation decreased blood cholesterol levels and increased bile acid synthesis.Demirel Kars 2014, NOLE administered to mice orally for 20 days resulted in substantial decreases in liver marker enzymes, as well as in cholesterol and TG levels. Oleander was detected in the urine at a concentration of 3.2 ng/mL and in the serum at a concentration of 8.4 ng/mL.Bavunoglu 2016, A 33-year-old woman who ingested 25 g of N. oleander leaves boiled in 350 mL of water for 20 minutes developed headache, vomiting, bradycardia, and hyperkalemia. I have researched a bit and found that harmful topical applications are from raw materials, are rare and generally an allergic reaction. Homeopathic Contents: 15 ml, 20% alcohol. Available for Android and iOS devices. I was looking into the Nerium claims. Temporary relief of symptoms of fever, aches and pains associated with flu, colds, and respiratory distress of flu-like symptoms. Treatment for a local skin reaction from oleander include taking an over-the-counter antihistamine. Although consuming oleander and using it as a topical preparation is not recommended for anyone, it can be especially dangerous for pregnant women or those who are breast feeding. Digoxin immune Fab (ovine) injection (DigiFab) was administered 22 hours postingestion, with improvement observed 3 hours after treatment.Pao-Franco 2017, Mice and rats administered aqueous leaf and flower extracts of N. oleander via oral gavage at doses of 10 mg/kg, 12.5 mg/kg, 15 mg/kg, and 20 mg/kg displayed signs of toxicity, including anorexia, nervousness, depression, restlessness, crying, ataxia, pawing of the ground, convulsions, falling, and turning of the head backwards. Nerium oleander (N.O) (Apocynaceae) is an ornamental shrub distributed originally in the Mediterranean region, subtropical Asia, and the Indo-Pakistan subcontinent but is now growing in many parts of the world such as Australia, USA, China, and Middle East countries . After looking into it a bit, I would feel more confident applying Nerium-AD than I would having Botox injections. Inhibits NF-kB factor in cancer cells 4. It is native to northern Africa, Southeast Asia, and parts of the Mediterranean. Oleander is used for heart conditions, asthma, epilepsy, cancer, painful menstrual periods, leprosy, malaria, ringworm, indigestion, and venereal disease; and to cause abortions. The symptoms of toxicity typically occur within three hours of consumption and without emergency medical intervention, serious health consequences can occur. Oleander intoxication can negatively impact the lungs, kidneys, spleen, and muscle tissue. This product may be unsafe when used before surgery or other medical procedures. N. oleander, is used for treatment of some skin problems edema, leprosy as traditional medicine application. Oleander 4X, Incubation. The patient was also given four 25 g doses of activated charcoal.Wong 2018, In a retrospective review of calls to one poison control center over 7 years related to human exposure to plants, one of the most common reasons for calls was oleander poisoning.Enfield 2018, A dog presented to a clinic 24 hours postingestion of an unknown amount of oleander leaves with detectable levels of digoxin (0.7 ng/mL); with no history of cardiac glycoside administration, the measured level was determined to be a result of oleander ingestion, confirming a diagnosis of oleander toxicosis. Contains tremendous immune boosting action 2. I am not a doctor. Last updated on Nov 23, 2020. A second horse from the same farm experienced lethargy and anorexia for 6 hours, with further deterioration 12 hours later. This is only a brief summary of general information about this product. It grows to between 2 and 5 m in height and has long, narrow leaves almost 13 to 30 cm in length and typically grouped in threes around the stem. From which you can learn a lot of new and interesting things, for example, that: Nerium Nerium oleander is a shrub or small tree in the dogbane family Apocynaceae, toxic in all its parts. Because of its poisonous nature it is only used externally. Potassium concentration rose from 4.3 mmol/L to 5.5 mmol/L within 1 hour of arrival, prompting administration of 2 additional vials of DigiFab. Include itching, hives, redness, and leprosy information does not replace information you receive from your care!, foods, or approved for treating any patient or health condition endorse this product Contents! Is highly poisonous to humans, pets, livestock and birds due to considerable. Typically occur within three hours of consumption and without emergency medical intervention, health... 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